| Season | Team | League | GP | G | A | TP | PIM | Playoffs | GP | G | A | TP | PIM | |
| 2008-2009 | Eau Claire Memorial High | USHS-WI | 23 | 2 | 20 | 22 | 16 | | | ||||||
| Team Wisconsin | UMHSEHL | 22 | 3 | 7 | 10 | - | | | |||||||
| 2009-2010 | USNTDP Juniors | USHL | 35 | 0 | 5 | 5 | 34 | | | ||||||
| U.S. National U17 Team | NTDP | 52 | 0 | 8 | 8 | 52 | | | |||||||
| U.S. National U18 Team | NTDP | 1 | 0 | 0 | 0 | 2 | | | |||||||
| USA U17 | WHC-17 | 6 | 0 | 1 | 1 | 6 | | | |||||||
| USA U17 (all) | International-Jr | 12 | 0 | 3 | 3 | 12 | | | |||||||
| 2010-2011 | USNTDP Juniors | USHL | 19 | 2 | 4 | 6 | 4 | | | ||||||
| U.S. National U18 Team | NTDP | 46 | 4 | 12 | 16 | 14 | | | |||||||
| USA U18 | WJC-18 | 6 | 0 | 1 | 1 | 0 | | | |||||||
| 2011-2012 | Univ. of Wisconsin | NCAA | 26 | 3 | 9 | 12 | 12 | | | ||||||
| 2012-2013 | Univ. of Wisconsin | NCAA | 38 | 3 | 18 | 21 | 50 | | | ||||||
| USA U20 | WJC-20 | 7 | 3 | 3 | 6 | 16 | | | |||||||
| 2013-2014 | Univ. of Wisconsin | NCAA | 36 | 8 | 17 | 25 | 53 | | | ||||||
| Buffalo Sabres | NHL | 7 | 0 | 1 | 1 | 15 | | | |||||||
| USA | WC | 8 | 0 | 0 | 0 | 2 | | | |||||||
| 2014-2015 | Buffalo Sabres | NHL | 2 | 0 | 0 | 0 | 0 | | | ||||||
| Rochester Americans | AHL | 57 | 5 | 24 | 29 | 50 | | | |||||||
| 2015-2016 | Buffalo Sabres | NHL | 77 | 4 | 10 | 14 | 51 | | | ||||||
| Rochester Americans | AHL | 1 | 0 | 0 | 0 | 0 | | | |||||||
| USA | WC | 8 | 1 | 1 | 2 | 0 | | | |||||||
| 2016-2017 | Buffalo Sabres | NHL | 76 | 3 | 17 | 20 | 26 | | | ||||||
| 2017-2018 | Buffalo Sabres | NHL | 53 | 3 | 9 | 12 | 26 | | | ||||||
| 2018-2019 | Buffalo Sabres | NHL | 59 | 4 | 10 | 14 | 35 | | | ||||||
| 2019-2020 | Buffalo Sabres | NHL | 66 | 3 | 10 | 13 | 41 | | | ||||||
| 2020-2021 | Buffalo Sabres | NHL | 13 | 1 | 2 | 3 | 9 | | | ||||||
| 2021-2022 | Chicago Blackhawks | NHL | 75 | 4 | 18 | 22 | 33 | | | ||||||
| 2022-2023 | Chicago Blackhawks | NHL | 55 | 2 | 18 | 20 | 27 | | | ||||||
| Toronto Maple Leafs | NHL | 21 | 1 | 4 | 5 | 29 | | | Playoffs | 11 | 0 | 2 | 2 | 10 | |
| 2023-2024 | Toronto Maple Leafs | NHL | 73 | 8 | 20 | 28 | 56 | | | Playoffs | 7 | 1 | 0 | 1 | 4 |
| 2024-2025 | Toronto Maple Leafs | NHL | 66 | 2 | 21 | 23 | 40 | | | Playoffs | 13 | 0 | 4 | 4 | 2 |
| 2025-2026 | Toronto Maple Leafs | NHL | 80 | 5 | 20 | 25 | 64 | | | ||||||
| 2026-2027 | Toronto Maple Leafs | NHL | - | - | - | - | - | | |