| Season | Team | League | GP | G | A | TP | PIM | Playoffs | GP | G | A | TP | PIM | |
| 2010-2011 | Boston Jr. Bruins | EmJHL | 40 | 15 | 21 | 36 | 16 | | | Playoffs | 7 | 2 | 5 | 7 | 6 |
| 2011-2012 | Boston Jr. Bruins | EmJHL | 36 | 39 | 47 | 86 | 36 | | | Playoffs | 3 | 0 | 0 | 0 | 0 |
| Boston Jr. Bruins | EJHL | 3 | 0 | 0 | 0 | 0 | | | |||||||
| USA U16 | YOG | 6 | 2 | 4 | 6 | 4 | | | |||||||
| 2012-2013 | USNTDP Juniors | USHL | 35 | 13 | 14 | 27 | 14 | | | ||||||
| U.S. National U17 Team | NTDP | 36 | 19 | 15 | 34 | 16 | | | |||||||
| U.S. National U18 Team | NTDP | 22 | 10 | 8 | 18 | 14 | | | |||||||
| USA U17 | WHC-17 | 5 | 3 | 0 | 3 | 2 | | | |||||||
| USA U18 | WJC-18 | 7 | 1 | 1 | 2 | 6 | | | |||||||
| 2013-2014 | USNTDP Juniors | USHL | 24 | 20 | 25 | 45 | 20 | | | ||||||
| U.S. National U18 Team | NTDP | 53 | 38 | 49 | 87 | 28 | | | |||||||
| USA U18 | WJC-18 | 7 | 5 | 5 | 10 | 2 | | | |||||||
| USA U20 | WJC-20 | 5 | 1 | 4 | 5 | 0 | | | |||||||
| 2014-2015 | Boston Univ. | NCAA | 40 | 26 | 45 | 71 | 28 | | | ||||||
| USA U20 | WJC-20 | 5 | 1 | 3 | 4 | 6 | | | |||||||
| USA | WC | 10 | 2 | 5 | 7 | 8 | | | |||||||
| 2015-2016 | Buffalo Sabres | NHL | 81 | 24 | 32 | 56 | 22 | | | ||||||
| 2016-2017 | Buffalo Sabres | NHL | 61 | 24 | 33 | 57 | 22 | | | ||||||
| Team North America | WCup | 3 | 1 | 1 | 2 | 0 | | | |||||||
| USA | WC | 8 | 0 | 5 | 5 | 4 | | | |||||||
| 2017-2018 | Buffalo Sabres | NHL | 67 | 25 | 39 | 64 | 32 | | | ||||||
| 2018-2019 | Buffalo Sabres | NHL | 77 | 28 | 54 | 82 | 26 | | | ||||||
| USA | WC | 8 | 2 | 6 | 8 | 2 | | | |||||||
| 2019-2020 | Buffalo Sabres | NHL | 68 | 36 | 42 | 78 | 34 | | | ||||||
| 2020-2021 | Buffalo Sabres | NHL | 21 | 2 | 16 | 18 | 6 | | | ||||||
| 2021-2022 | Vegas Golden Knights | NHL | 34 | 14 | 11 | 25 | 10 | | | ||||||
| 2022-2023 | Vegas Golden Knights | NHL | 67 | 27 | 39 | 66 | 6 | | | Playoffs | 22 | 6 | 20 | 26 | 14 |
| 2023-2024 | Vegas Golden Knights | NHL | 63 | 31 | 37 | 68 | 27 | | | Playoffs | 7 | 3 | 4 | 7 | 0 |
| 2024-2025 | Vegas Golden Knights | NHL | 77 | 28 | 66 | 94 | 8 | | | Playoffs | 11 | 1 | 9 | 10 | 0 |
| USA | NHL 4 Nations | 4 | 0 | 4 | 4 | 0 | | | |||||||
| 2025-2026 | Vegas Golden Knights | NHL | 74 | 27 | 63 | 90 | 18 | | | Playoffs | 17 | 2 | 17 | 19 | 12 |
| USA Olympics | OG | 6 | 2 | 4 | 6 | 2 | | |